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ATR and Chk1 kinases are required forcell survival [ 118], and inactivation of these kinases is not a frequent event in onco-genesis.
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Studies looking at BAX and BAK genenegative mice have determined that Tregs use LAG ligation of DC MHC class II (see below)induce DC apoptosis in a mitochondrial-induced fashion (Chen 2011). Thisactivation of the Oct-4 in non-CSC allows them to regenerate into CSC. A nicotine inhaler allowsmore flexible dosing and mimics the hand-to-mouthbehavior of smoking A nicotine inhaler allowsmore flexible dosing and mimics the hand-to-mouthbehavior of smoking. Romano RA et al (2012) DNp63 knockout mice reveal its indispensable role as a master regu-lator of epithelial development and differentiation.